PANK1

Across TCGA patient cohorts, PANK1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANK1-associated genes across cancer lineages are eIF4E, ATM, and Ku80. Each is linked with PANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK1-to-partner and partner-to-PANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PANK1-low versus PANK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK1→partner) and Y-score (partner→PANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.218	+3.321	.026	.010	3	2
UCEC	ATM →	-0.730	-3.700	<.001	.001	3	2
UCEC	Ku80 →	+0.339	+2.331	.002	.019	3	1
UCEC	MAPK_pT202_Y204 →	-0.486	-2.321	.026	.034	3	1
UCEC	MEK1 →	+0.377	+3.321	.027	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.540	-2.321	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by PANK1 expression — UCEC

Explore this box plot interactively →