PANK1

Across TCGA cell cohorts, PANK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,659 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PANK1-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, DNA strand elongation involved in DNA replication, and DNA strand elongation. Each is linked with PANK1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PANK1-to-partner and partner-to-PANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by PANK1-low versus PANK1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK1→partner) and Y-score (partner→PANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.077	+1.186	<.001	<.001	3	14
BONE	DNA strand elongation involved in DNA replication →	+0.198	+0.761	<.001	.001	3	14
BONE	DNA strand elongation →	+0.176	+0.939	.009	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.062	+1.085	.001	.001	3	13
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.138	+0.820	<.001	<.001	3	13
SOFT_TISSUE	Lagging strand elongation →	+0.131	+0.873	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,659 associations by consensus.

Positive regulation of double-strand break repair by PANK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →