PANK1

Across TCGA cell cohorts, PANK1 mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PANK1-associated genes across cancer lineages are CBY1, MRPS15, and CAMK1. Each is linked with PANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK1-to-partner and partner-to-PANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by PANK1-low versus PANK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK1→partner) and Y-score (partner→PANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.639	+3.299	.001	.004	3	1
LARGE_INTESTINE	MRPS15 →	+0.575	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CAMK1 →	+1.486	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PPA2 →	+0.645	+3.212	.002	.006	3	1
LARGE_INTESTINE	ADAM21 →	+0.487	+3.247	<.001	.004	3	1
LARGE_INTESTINE	TMEM50B →	+0.521	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

CBY1 by PANK1 expression — LARGE_INTESTINE

Explore this box plot interactively →