PAN3

Across TCGA pan-cancer cohorts, PAN3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PAN3 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAN3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PAN3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where PAN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.915	0.595	<.001	77	view →
PDAC	OS	Quartile	III,IV	0.947	0.453	.006	4	view →
LUAD	OS	Median	All	0.939	0.674	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PAN3–CCRCC (DFS)

Open the CCRCC breakdown →