PAN3

Across TCGA pan-cancer cohorts, PAN3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PAN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAN3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where PAN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.038	<.001	10	view →
KICH	Female	II,III,IV	−1.324	<.001	8	view →
THCA	All	All	−0.433	<.001	7	view →
STAD	All	II,III,IV	+0.759	.003	6	view →
CHOL	Male	All	+2.199	<.001	5	view →
UCEC	All	IV	−0.945	.001	4	view →
READ	All	All	+0.746	.011	4	view →
LIHC	Female	All	+0.590	<.001	4	view →
HNSC	All	All	+0.336	.017	4	view →
KIRC	All	All	+0.274	<.001	3	view →
LUSC	Female	II,III,IV	−0.772	.006	1	view →
ESCA	All	All	+0.542	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PAN3–COAD

Open the COAD breakdown →