PAN3

Across TCGA cell cohorts, PAN3 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAN3-associated genes across cancer lineages are OR6N1, KRTDAP, and OXT. Each is linked with PAN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAN3-to-partner and partner-to-PAN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6N1 grouped by PAN3-low versus PAN3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAN3→partner) and Y-score (partner→PAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR6N1 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Leukemia	KRTDAP →	+0.092	+3.106	<.001	.005	3	1
SKIN	OXT →	+0.070	+4.977	<.001	.007	3	1
SKIN	C5orf52 →	+0.062	+5.415	<.001	.004	3	1
CNS	FSHB →	+0.024	+4.321	<.001	.009	3	1
LARGE_INTESTINE	GSR →	+0.770	+3.364	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

OR6N1 by PAN3 expression — URINARY_TRACT

Explore this box plot interactively →