PAN3-AS1

Across TCGA pan-cancer cohorts, PAN3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PAN3-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PAN3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAN3-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCS show a favorable association.

ACC, PAAD, and COAD are the cancer types where PAN3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.226	0.675	<.001	87	view →
PAAD	OS	Tertile	All	0.670	0.309	<.001	66	view →
COAD	OS	Tertile	All	0.396	0.715	.002	50	view →
UCS	DFS	Quartile	II,III,IV	0.680	0.114	.002	42	view →
LUAD	OS	Tertile	II,III,IV	0.778	0.626	.005	29	view →
MESO	OS	Median	III,IV	0.476	0.297	.012	20	view →
LGG	OS	Median	All	0.653	0.403	<.001	19	view →
BLCA	OS	Quartile	II,III,IV	0.776	0.625	.012	17	view →
HNSC	DFS	Tertile	IV	0.766	0.572	.004	17	view →
THYM	DFS	Tertile	All	0.931	0.753	.008	16	view →
PRAD	DFS	Median	All	0.837	0.925	.001	16	view →
THCA	DFS	Quartile	All	0.937	0.812	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PAN3-AS1–ACC (DFS)

Open the ACC breakdown →