PAN3-AS1

Across TCGA pan-cancer cohorts, PAN3-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PAN3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PAN3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PAN3-AS1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where PAN3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAN3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.308	<.001	11	view →
LUAD	Female	III,IV	−1.455	<.001	9	view →
LUSC	Female	II,III,IV	−0.937	<.001	8	view →
KIRC	Male	III,IV	−0.473	<.001	8	view →
COAD	All	II,III,IV	+0.696	<.001	7	view →
UCEC	All	All	−1.080	<.001	6	view →
BRCA	All	II,III,IV	−0.769	<.001	6	view →
KIRP	All	All	−0.373	.010	6	view →
THCA	All	All	−0.356	<.001	6	view →
CHOL	All	All	+1.097	<.001	5	view →
LIHC	Female	All	+0.406	<.001	5	view →
BLCA	All	IV	−0.885	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PAN3-AS1–KICH

Open the KICH breakdown →