PAN2

Across TCGA patient cohorts, PAN2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,212 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAN2-associated genes across cancer lineages are PLA2G6, XPO4, and CDK8. Each is linked with PAN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAN2-to-partner and partner-to-PAN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAN2 versus PLA2G6 in BRCA, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAN2→partner) and Y-score (partner→PAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLA2G6 →	+0.890	+0.183	<.001	<.001	3	4
HNSC	XPO4 →	+0.420	+0.133	.008	.007	3	3
LSCC	CDK8 →	+0.495	+0.270	<.001	<.001	3	3
LSCC	DNAJC14 →	+0.413	+0.184	<.001	<.001	3	3
OV	PRPSAP2 →	+0.532	+0.270	.005	.002	3	3
LSCC	PAN3 →	+0.390	+0.222	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,212 associations by consensus.

PAN2 vs PLA2G6 — BRCA

Explore this scatter interactively →