PAM

Across TCGA patient cohorts, PAM RNA expression is significantly associated with the RNA expression of many other genes, with 19,694 significant associations in total. UVM shows the largest number of these associations.

The most reproducible PAM-associated genes across cancer lineages are FBXO38, SLC25A46, and TTC37. Each is linked with PAM in more than 32 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAM versus FBXO38 in UVM, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	FBXO38 →	+0.961	+1.188	<.001	<.001	3	33
UVM	SLC25A46 →	+1.127	+1.218	<.001	<.001	3	33
UVM	TTC37 →	+1.362	+1.273	<.001	<.001	3	33
UVM	PJA2 →	+1.231	+1.176	<.001	<.001	3	33
THYM	ITGB1 →	+2.036	+1.425	<.001	<.001	3	33
KICH	CSNK1G3 →	+1.095	+1.634	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,694 associations by consensus.

PAM vs FBXO38 — UVM

Explore this scatter interactively →