PAM

Across TCGA patient cohorts, PAM RNA expression is significantly associated with the protein abundance of many other proteins, with 14,865 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PAM-associated proteins across cancer lineages are P4HA2, PAM_S946, and GBE1. Each is linked with PAM in more than 5 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAM versus P4HA2 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	P4HA2 →	+0.779	+1.033	<.001	<.001	3	6
LUAD	PAM_S946 →	+0.934	+0.745	<.001	<.001	3	6
BRCA	GBE1 →	+0.314	+0.861	.001	<.001	3	6
CCRCC	PAM_S918 →	+1.125	+0.803	.005	.009	3	5
BRCA	RAI14 →	+0.360	+0.793	<.001	<.001	3	5
PDAC	CAPN2 →	+0.341	+0.413	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,865 associations by consensus.

PAM vs P4HA2 — BRCA

Explore this scatter interactively →