PAM

Across TCGA patient cohorts, PAM mutation is significantly associated with the RNA expression of many other genes, with 5,646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAM-associated genes across cancer lineages are MELK, TIPIN, and OPN1SW. Each is linked with PAM in more than 2 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MELK grouped by PAM-low versus PAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.948	+2.283	<.001	<.001	3	3
UCEC	TIPIN →	+0.604	+2.606	<.001	<.001	3	3
SKCM	OPN1SW →	+0.631	+2.267	.005	.001	3	3
SKCM	PTS →	+0.511	+2.340	.001	.003	3	3
UCEC	ARRDC3-AS1 →	+0.207	+2.659	.001	<.001	3	3
UCEC	EIF3JP1 →	+0.129	+1.575	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,646 associations by consensus.

MELK by PAM expression — UCEC

Explore this box plot interactively →