PAM

Across TCGA patient cohorts, PAM mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAM-associated genes across cancer lineages are ATM, Rictor_pT1135, and eIF4E. Each is linked with PAM in more than 2 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PAM-low versus PAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.481	-2.000	.001	.009	3	3
SKCM	Rictor_pT1135 →	+0.242	+2.186	.002	.034	3	2
UCEC	eIF4E →	+0.154	+3.472	.026	.002	3	2
UCEC	mTOR_pS2448 →	-0.112	-1.392	.022	.019	3	2
UCEC	PDCD4 →	-0.594	-2.999	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.415	+1.720	.016	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by PAM expression — UCEC

Explore this box plot interactively →