PAM

Across TCGA cell cohorts, PAM mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAM-associated genes across cancer lineages are OR11H1, CCDC182, and DDI1. Each is linked with PAM in more than 1 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by PAM-low versus PAM-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR11H1 →	+0.099	+4.285	<.001	.003	3	1
BLOOD_Myeloma	CCDC182 →	+0.029	+3.906	<.001	.009	3	1
BLOOD_Myeloma	DDI1 →	+0.007	+4.285	<.001	.003	3	1
BLOOD_Myeloma	HTR1A →	+0.012	+4.754	<.001	<.001	3	1
SKIN	PRAC1 →	+0.164	+3.658	.002	.005	3	1
SKIN	TRIM60 →	+0.004	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR11H1 by PAM expression — BLOOD_Myeloma

Explore this box plot interactively →