PALMD

Across TCGA cell cohorts, PALMD mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PALMD-associated genes across cancer lineages are USP17L18, NUDT10, and ZNF831. Each is linked with PALMD in more than 1 cancer types. Because this analysis shows association rather than direction, both PALMD-to-partner and partner-to-PALMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L18 grouped by PALMD-low versus PALMD-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALMD→partner) and Y-score (partner→PALMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP17L18 →	+0.006	+4.887	<.001	.009	3	1
LARGE_INTESTINE	NUDT10 →	+0.309	+3.070	.005	.002	3	1
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	TEX101 →	+0.143	+3.708	.001	.004	3	1
LARGE_INTESTINE	VAX1 →	+0.977	+4.005	<.001	<.001	3	1
LARGE_INTESTINE	SMIM43 →	+0.246	+2.688	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

USP17L18 by PALMD expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →