PALM2AKAP2

Across TCGA patient cohorts, PALM2AKAP2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALM2AKAP2-associated genes across cancer lineages are ASNS, c-Kit, and mTOR_pS2448. Each is linked with PALM2AKAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PALM2AKAP2-to-partner and partner-to-PALM2AKAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PALM2AKAP2-low versus PALM2AKAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALM2AKAP2→partner) and Y-score (partner→PALM2AKAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.333	+1.000	<.001	.029	3	3
UCEC	c-Kit →	-0.174	-1.584	.003	<.001	3	3
UCEC	mTOR_pS2448 →	-0.080	-1.302	.034	.010	3	2
UCEC	PCNA →	+0.186	+1.584	<.001	<.001	3	2
UCEC	PDCD4 →	-0.480	-1.678	<.001	<.001	3	2
UCEC	RAD51 →	+0.088	+1.201	.012	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ASNS by PALM2AKAP2 expression — UCEC

Explore this box plot interactively →