PALD1

Across TCGA cell cohorts, PALD1 mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PALD1-associated genes across cancer lineages are MAGEB4, PHOX2B, and TBC1D3. Each is linked with PALD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PALD1-to-partner and partner-to-PALD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PALD1-low versus PALD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALD1→partner) and Y-score (partner→PALD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.000	<.001	.003	3	2
BLOOD_Leukemia	PHOX2B →	+0.019	+4.365	<.001	.002	3	2
SKIN	TBC1D3 →	+0.680	+2.882	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.451	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.632	+3.137	.001	.007	3	1
LARGE_INTESTINE	ATP8B4 →	+0.290	+3.131	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

MAGEB4 by PALD1 expression — LARGE_INTESTINE

Explore this box plot interactively →