PAK4

Across TCGA pan-cancer cohorts, PAK4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAK4 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PAK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAK4 expression acts as an unfavorable survival marker.

LUAD, CCRCC, and PDAC are the cancer types where PAK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.332	0.878	<.001	27	view →
CCRCC	DFS	Median	All	0.600	0.879	.002	16	view →
PDAC	OS	Tertile	IV	0.455	0.836	.024	6	view →
GBM	OS	Tertile	All	0.694	0.825	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAK4–LUAD (DFS)

Open the LUAD breakdown →