PAK4

Across TCGA patient cohorts, PAK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,995 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAK4-associated proteins across cancer lineages are UBA2, SIPA1L3, and XRCC1. Each is linked with PAK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PAK4-to-partner and partner-to-PAK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAK4 versus UBA2 in LSCC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK4→partner) and Y-score (partner→PAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBA2 →	+0.369	+0.777	<.001	<.001	3	5
GBM	SIPA1L3 →	+0.377	+0.461	<.001	<.001	3	5
GBM	XRCC1 →	+0.387	+0.445	<.001	<.001	3	5
PDAC	MED29 →	+0.275	+0.672	<.001	<.001	3	5
GBM	SAE1 →	+0.338	+0.287	<.001	<.001	3	5
LSCC	SUPT5H →	+0.334	+0.694	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,995 associations by consensus.

PAK4 vs UBA2 — LSCC

Explore this scatter interactively →