PAK4

Across TCGA patient cohorts, PAK4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,135 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAK4-associated genes across cancer lineages are TIMM50, MED29, and PSMD8. Each is linked with PAK4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PAK4-to-partner and partner-to-PAK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAK4 versus TIMM50 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK4→partner) and Y-score (partner→PAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TIMM50 →	+0.691	+0.361	<.001	<.001	3	8
LSCC	MED29 →	+0.551	+0.385	<.001	<.001	3	7
LSCC	PSMD8 →	+0.658	+0.421	<.001	<.001	3	6
BRCA	SPINT2 →	+1.131	+0.538	<.001	<.001	3	6
UCEC	TNFSF8 →	-0.593	-0.232	.009	.004	2	6
HNSC	IL16 →	-0.612	-0.350	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,135 associations by consensus.

PAK4 vs TIMM50 — LSCC

Explore this scatter interactively →