PAK4

Across TCGA patient cohorts, PAK4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK4-associated genes across cancer lineages are PDCD4, Notch1, and Stathmin. Each is linked with PAK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK4-to-partner and partner-to-PAK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PAK4-low versus PAK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK4→partner) and Y-score (partner→PAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.785	-2.999	.001	.035	3	3
UCEC	Notch1 →	+0.223	+2.820	.002	.035	3	2
UCEC	Stathmin →	+0.186	+3.321	.009	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.689	+2.827	.026	.035	3	2
UCEC	STAT3_pY705 →	-0.544	-3.321	<.001	.010	3	1
UCEC	PCNA →	+0.317	+3.000	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by PAK4 expression — UCEC

Explore this box plot interactively →