PAK4

Across TCGA cell cohorts, PAK4 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAK4-associated genes across cancer lineages are CCDC195, OR51A2, and OR51A4. Each is linked with PAK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK4-to-partner and partner-to-PAK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC195 grouped by PAK4-low versus PAK4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK4→partner) and Y-score (partner→PAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC195 →	+0.034	+2.560	.001	.008	3	2
LUNG_NSCLC_LUAD	OR51A2 →	+0.011	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR51A4 →	+0.016	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR51F1 →	+0.030	+4.266	<.001	.004	3	1
OVARY	PPY →	+0.241	+4.029	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.500	+3.295	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CCDC195 by PAK4 expression — LARGE_INTESTINE

Explore this box plot interactively →