PAK3

Across TCGA cell cohorts, PAK3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PAK3-associated genes across cancer lineages are HSFY2, OR52N5, and OR56B1. Each is linked with PAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK3-to-partner and partner-to-PAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by PAK3-low versus PAK3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK3→partner) and Y-score (partner→PAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HSFY2 →	+0.019	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR52N5 →	+0.171	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR56B1 →	+0.048	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.486	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SLC22A6 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HSFY2 by PAK3 expression — SKIN

Explore this box plot interactively →