PAK2

Across TCGA patient cohorts, PAK2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK2-associated genes across cancer lineages are Cyclin-B1, p38-MAPK_pT180_Y182, and eEF2. Each is linked with PAK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK2-to-partner and partner-to-PAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PAK2-low versus PAK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK2→partner) and Y-score (partner→PAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.924	+3.584	<.001	.002	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.685	-3.584	<.001	.002	3	2
UCEC	eEF2 →	+0.443	+2.115	.004	.019	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.321	.002	.010	3	1
UCEC	FASN →	+0.440	+2.115	.010	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.140	-2.449	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-B1 by PAK2 expression — UCEC

Explore this box plot interactively →