PAK2

Across TCGA cell cohorts, PAK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,876 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAK2-associated GO terms across cancer lineages are Negative regulation of protein-containing complex disassembly, Transcription elongation by RNA polymerase II, and Positive regulation of mitotic cytokinesis. Each is linked with PAK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PAK2-to-partner and partner-to-PAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex disassembly grouped by PAK2-low versus PAK2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK2→partner) and Y-score (partner→PAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of protein-containing complex disassembly →	+0.077	+0.425	<.001	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Transcription elongation by RNA polymerase II →	+0.071	+0.620	<.001	<.001	3	14
BREAST	Positive regulation of mitotic cytokinesis →	+0.130	+0.681	.001	.002	3	13
LARGE_INTESTINE	Negative regulation of cilium assembly →	+0.045	+0.580	.005	<.001	3	13
LARGE_INTESTINE	Positive regulation of cytokinesis →	+0.087	+0.536	<.001	.003	3	13
LARGE_INTESTINE	Negative regulation of autophagosome maturation →	+0.105	+0.579	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,876 associations by consensus.

Negative regulation of protein-containing complex disassembly by PAK2 expression — LIVER

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