PAICSP4

Across TCGA pan-cancer cohorts, PAICSP4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PAICSP4 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PAICSP4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PAICSP4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and READ show a favorable association.

LUSC, ACC, and LIHC are the cancer types where PAICSP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.848	0.655	<.001	52	view →
ACC	DFS	Median	II,III,IV	0.381	0.666	.006	51	view →
LIHC	DFS	Median	All	0.450	0.648	<.001	50	view →
READ	DFS	Median	III,IV	0.875	0.624	<.001	44	view →
LUAD	OS	Tertile	All	0.746	0.862	<.001	36	view →
SARC	OS	Median	All	0.415	0.601	<.001	34	view →
LGG	OS	Tertile	All	0.689	0.844	<.001	30	view →
UVM	DFS	Quartile	All	0.406	0.981	<.001	26	view →
UCEC	DFS	Median	IV	0.286	0.650	.018	22	view →
KIRP	OS	Quartile	All	0.841	0.950	.004	20	view →
CESC	OS	Tertile	IV	0.066	0.839	.016	18	view →
OV	OS	Median	III,IV	0.874	0.797	.021	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PAICSP4–LUSC (OS)

Open the LUSC breakdown →