Q-omics provides the consensus-scored PAICSP4 profile across patient tissues and cancer cell-line models. PAICSP4 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, PAICSP4 is differentially expressed in 13, with the highest sampling consensus in COAD. Additionally, PAICSP4 RNA expression shows 17,680 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight LUSC, COAD, and GBM as cancer lineages where PAICSP4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PAICSP4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PAICSP4 survival associations across molecular data types. PAICSP4 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PAICSP4 RNA expression–survival associations across cancer types. High PAICSP4 expression shows unfavorable associations in ACC, LIHC, LUAD and SARC, but favorable associations in LUSC and READ. The LUSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for PAICSP4 RNA expression.
This table summarizes PAICSP4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for PAICSP4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PAICSP4 shows higher tumor expression in COAD, LUAD, HNSC, STAD, LUSC and BRCA. The COAD box plot shows higher PAICSP4 RNA expression in tumor versus normal tissue (log2 FC = +0.417, t-test p < 0.001).
This table shows molecular features associated with PAICSP4 in patient tissues and cancer cell lines. In patient samples, PAICSP4 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
