PAICS

Across TCGA pan-cancer cohorts, PAICS Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAICS data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PAICS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAICS expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, COAD, and READ are the cancer types where PAICS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.046	0.757	<.001	18	view →
COAD	OS	Median	III,IV	0.208	0.791	.008	9	view →
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
UCEC	DFS	Median	II,III,IV	0.906	0.440	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAICS–SKCM (DFS)

Open the SKCM breakdown →