PAICS

Across TCGA pan-cancer cohorts, PAICS RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PAICS’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PAICS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAICS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where PAICS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAICS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.208	<.001	12	view →
LUAD	Male	III,IV	+1.934	<.001	11	view →
COAD	Female	II,III,IV	+1.419	<.001	11	view →
HNSC	Male	All	+1.345	<.001	11	view →
KIRC	All	All	+0.344	<.001	11	view →
LUSC	Male	III,IV	+2.670	<.001	9	view →
STAD	All	III,IV	+1.708	<.001	9	view →
THCA	Male	All	−0.577	<.001	9	view →
LIHC	Male	All	+0.798	<.001	7	view →
BRCA	All	III,IV	+1.033	<.001	6	view →
UCEC	All	All	+0.919	<.001	6	view →
CHOL	All	All	+0.912	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PAICS–BLCA

Open the BLCA breakdown →