PAICS

Across TCGA pan-cancer cohorts, PAICS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PAICS data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAICS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAICS expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where PAICS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.596	0.876	<.001	63	view →
LUAD	OS	Median	All	0.617	1.000	<.001	36	view →
GBM	OS	Median	All	0.651	0.414	.002	7	view →
HNSC	DFS	Median	II,III,IV	0.749	0.549	.016	7	view →
UCEC	OS	Tertile	III,IV	1.000	0.483	.042	4	view →
LSCC	DFS	Quartile	II,III,IV	0.855	0.426	.012	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PAICS–CCRCC (DFS)

Open the CCRCC breakdown →