PAICS

Across TCGA patient cohorts, PAICS protein abundance is significantly associated with the RNA expression of many other genes, with 15,179 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAICS-associated genes across cancer lineages are PPAT, SHE, and CNRIP1. Each is linked with PAICS in more than 8 cancer types. Because this analysis shows association rather than direction, both PAICS-to-partner and partner-to-PAICS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAICS versus PPAT in LSCC, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAICS→partner) and Y-score (partner→PAICS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPAT →	+0.905	+0.582	<.001	<.001	3	9
LUAD	SHE →	-1.140	-0.373	<.001	<.001	3	8
UCEC	CNRIP1 →	-0.750	-0.303	<.001	<.001	3	7
UCEC	CLEC1A →	-0.560	-0.324	<.001	<.001	3	7
BRCA	EMCN →	-1.085	-0.397	<.001	<.001	3	7
HNSC	SRP72 →	+0.687	+0.370	.007	.009	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,179 associations by consensus.

PAICS vs PPAT — LSCC

Explore this scatter interactively →