PAICS

Across TCGA patient cohorts, PAICS mutation is significantly associated with the RNA expression of many other genes, with 1,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAICS-associated genes across cancer lineages are MIR301A, GNA13P1, and FTH1P27. Each is linked with PAICS in more than 1 cancer types. Because this analysis shows association rather than direction, both PAICS-to-partner and partner-to-PAICS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR301A grouped by PAICS-low versus PAICS-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAICS→partner) and Y-score (partner→PAICS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR301A →	+0.370	+5.149	<.001	.003	3	1
LIHC	GNA13P1 →	+0.076	+4.878	<.001	.005	3	1
LIHC	FTH1P27 →	+0.103	+4.776	<.001	.003	3	1
LIHC	LNX1-AS1 →	+0.054	+4.308	.003	.007	3	1
LUSC	TTTY4B →	+0.019	+7.924	<.001	.008	3	1
LUSC	TSPY21P →	+0.039	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,968 associations by consensus.

MIR301A by PAICS expression — LIHC

Explore this box plot interactively →