PAICS

Across TCGA cell cohorts, PAICS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,760 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PAICS-associated GO terms across cancer lineages are 'de novo' IMP biosynthetic process, Purine nucleoside monophosphate biosynthetic process, and 'de novo' AMP biosynthetic process. Each is linked with PAICS in more than 19 cancer types. Because this analysis shows association rather than direction, both PAICS-to-partner and partner-to-PAICS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' IMP biosynthetic process grouped by PAICS-low versus PAICS-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAICS→partner) and Y-score (partner→PAICS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	'de novo' IMP biosynthetic process →	+0.158	+0.894	<.001	.001	3	20
PANCREAS	Purine nucleoside monophosphate biosynthetic process →	+0.175	+1.405	<.001	<.001	3	19
LUNG_SCLC	'de novo' AMP biosynthetic process →	+0.241	+1.081	<.001	<.001	3	19
BLOOD_Myeloma	IMP metabolic process →	+0.145	+0.919	<.001	<.001	3	19
BONE	Nucleobase biosynthetic process →	+0.196	+1.269	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.186	+1.719	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,760 associations by consensus.

'de novo' IMP biosynthetic process by PAICS expression — BLOOD_Myeloma

Explore this box plot interactively →