PAGR1

Across TCGA pan-cancer cohorts, PAGR1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAGR1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PAGR1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PAGR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where PAGR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.920	0.195	.006	32	view →
HNSC	DFS	Median	III,IV	0.427	0.790	.003	29	view →
UCEC	DFS	Median	All	0.989	0.813	.001	22	view →
LSCC	DFS	Median	All	0.973	0.908	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAGR1–LUAD (DFS)

Open the LUAD breakdown →