PAGR1

Across TCGA pan-cancer cohorts, PAGR1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PAGR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PAGR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAGR1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where PAGR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAGR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.775	<.001	11	view →
THCA	Male	II,III,IV	−0.588	<.001	10	view →
LIHC	Male	II,III,IV	+1.063	<.001	9	view →
BLCA	All	All	+0.832	<.001	9	view →
KIRP	All	II,III,IV	+0.639	<.001	8	view →
STAD	All	II,III,IV	+0.810	<.001	7	view →
COAD	Male	All	+0.447	<.001	7	view →
BRCA	All	III,IV	+0.864	<.001	6	view →
KICH	All	All	−0.544	<.001	6	view →
KIRC	All	All	+0.272	.001	6	view →
LUSC	All	II,III,IV	+0.655	<.001	5	view →
UCEC	All	All	−0.487	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PAGR1–HNSC

Open the HNSC breakdown →