PAGR1

Across TCGA cell cohorts, PAGR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,776 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAGR1-associated GO terms across cancer lineages are DNA replication, Positive regulation of intracellular estrogen receptor signaling pathway, and DNA-templated DNA replication. Each is linked with PAGR1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PAGR1-to-partner and partner-to-PAGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by PAGR1-low versus PAGR1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGR1→partner) and Y-score (partner→PAGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication →	+0.111	+0.826	<.001	<.001	3	17
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.208	+1.047	<.001	.001	3	17
BLOOD_Myeloma	DNA-templated DNA replication →	+0.122	+0.825	<.001	<.001	3	17
OESOPHAGUS	Double-strand break repair via homologous recombination →	+0.089	+0.683	<.001	.005	3	16
OESOPHAGUS	Recombinational repair →	+0.093	+0.796	<.001	.002	3	16
LUNG_NSCLC_LUSC	Interstrand cross-link repair →	+0.086	+0.954	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,776 associations by consensus.

DNA replication by PAGR1 expression — BLOOD_Myeloma

Explore this box plot interactively →