PAGE5

Across TCGA patient cohorts, PAGE5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE5-associated genes across cancer lineages are JNK2, mTOR_pS2448, and p27_pT198. Each is linked with PAGE5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE5-to-partner and partner-to-PAGE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PAGE5-low versus PAGE5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE5→partner) and Y-score (partner→PAGE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.196	+2.584	.034	.011	3	1
UCEC	mTOR_pS2448 →	-0.155	-2.584	.026	.011	3	1
UCEC	p27_pT198 →	+0.108	+2.584	.030	.011	3	1
UCEC	AR →	-0.421	-3.000	.015	.036	3	1
UCEC	YB-1_pS102 →	+0.198	+3.321	.022	.010	3	1
UCEC	VHL →	-0.663	-3.000	.036	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by PAGE5 expression — UCEC

Explore this box plot interactively →