PAGE5

Across TCGA pan-cancer cohorts, PAGE5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PAGE5 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PAGE5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PAGE5 expression acts as an unfavorable survival marker, although some lineages such as LUSC and ACC show a favorable association.

LUSC, ACC, and SARC are the cancer types where PAGE5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.525	0.285	<.001	24	view →
ACC	DFS	Tertile	All	0.836	0.339	.006	23	view →
SARC	OS	Tertile	All	0.385	0.572	.002	21	view →
HNSC	DFS	Quartile	IV	0.763	0.448	.017	17	view →
KIRC	OS	Median	All	0.595	0.713	.013	13	view →
CHOL	OS	Median	II,III,IV	0.413	0.812	.023	12	view →
LUAD	DFS	Quartile	II,III,IV	0.732	0.478	.022	12	view →
PRAD	OS	Quartile	All	0.975	1.000	<.001	12	view →
SKCM	OS	Quartile	III,IV	0.610	0.258	.003	11	view →
MESO	OS	Tertile	III,IV	0.137	0.593	.007	9	view →
TGCT	DFS	Median	All	0.806	0.583	.018	8	view →
STAD	DFS	Tertile	IV	0.096	0.700	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PAGE5–LUSC (OS)

Open the LUSC breakdown →