PAGE2

Across TCGA patient cohorts, PAGE2 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE2-associated genes across cancer lineages are RNU6-753P, RNU6-982P, and FAM90A12P. Each is linked with PAGE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE2-to-partner and partner-to-PAGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-753P grouped by PAGE2-low versus PAGE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE2→partner) and Y-score (partner→PAGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-753P →	+0.448	+6.060	<.001	<.001	3	2
SKCM	RNU6-982P →	+0.408	+5.970	<.001	.002	3	1
SKCM	FAM90A12P →	+0.024	+5.436	.001	.005	3	1
SKCM	MIR3165 →	+0.464	+5.097	.001	.008	3	1
BRCA	RNU6-1320P →	+0.282	+8.055	<.001	.007	3	1
BRCA	KRTAP9-10P →	+0.158	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

RNU6-753P by PAGE2 expression — UCEC

Explore this box plot interactively →