PAGE2

Across TCGA pan-cancer cohorts, PAGE2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PAGE2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PAGE2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAGE2 is over-expressed in tumor.

KIRC, BRCA, and LIHC are the cancer types where PAGE2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAGE2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.039	<.001	7	view →
BRCA	Female	All	+0.279	.005	4	view →
LIHC	All	All	+1.043	.001	2	view →
LUSC	All	All	+0.848	.006	2	view →
LUAD	All	All	+0.404	.042	1	view →
COAD	Female	IV	+0.265	.003	1	view →
READ	All	All	+0.116	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PAGE2–KIRC

Open the KIRC breakdown →