PAGE1

Across TCGA patient cohorts, PAGE1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE1-associated genes across cancer lineages are MSH6, N-Cadherin, and Shc_pY317. Each is linked with PAGE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE1-to-partner and partner-to-PAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by PAGE1-low versus PAGE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE1→partner) and Y-score (partner→PAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.353	-2.999	.027	.035	3	1
UCEC	N-Cadherin →	+0.264	+2.179	.009	.034	3	1
UCEC	Shc_pY317 →	-0.172	-3.169	.019	.019	3	1
UCEC	Bid →	+0.139	+2.459	.016	.020	3	1
UCEC	GATA6 →	-0.204	-3.000	.011	.035	2	1
UCEC	P-Cadherin →	-0.161	-2.990	.020	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSH6 by PAGE1 expression — UCEC

Explore this box plot interactively →