PAFAH1B3

Across TCGA patient cohorts, PAFAH1B3 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAFAH1B3-associated genes across cancer lineages are MIR4672, EEF1E1-BLOC1S5, and RNA5SP333. Each is linked with PAFAH1B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAFAH1B3-to-partner and partner-to-PAFAH1B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4672 grouped by PAFAH1B3-low versus PAFAH1B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAFAH1B3→partner) and Y-score (partner→PAFAH1B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4672 →	+0.596	+3.041	<.001	.008	3	1
UCEC	EEF1E1-BLOC1S5 →	+0.051	+4.132	<.001	.009	3	1
UCEC	RNA5SP333 →	+0.183	+4.727	<.001	.003	3	1
UCEC	RNU4-13P →	+0.220	+4.727	<.001	.003	3	1
UCEC	MIR760 →	+0.522	+3.282	.002	.004	3	1
UCEC	RNU6-1228P →	+0.228	+4.727	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MIR4672 by PAFAH1B3 expression — UCEC

Explore this box plot interactively →