PAFAH1B1

Across TCGA pan-cancer cohorts, PAFAH1B1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PAFAH1B1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAFAH1B1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PAFAH1B1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where PAFAH1B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	38	view →
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	36	view →
HNSC	DFS	Median	III,IV	0.911	0.696	.018	12	view →
UCEC	OS	Quartile	III,IV	0.329	1.000	.013	12	view →
GBM	OS	Tertile	All	0.378	0.662	.034	6	view →
LUAD	DFS	Median	All	0.917	0.681	.039	3	view →
PDAC	DFS	Median	All	0.821	0.766	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PAFAH1B1–CCRCC (DFS)

Open the CCRCC breakdown →