PAFAH1B1

Across TCGA pan-cancer cohorts, PAFAH1B1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PAFAH1B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PAFAH1B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAFAH1B1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where PAFAH1B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAFAH1B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.569	<.001	11	view →
THCA	Male	All	−0.581	<.001	9	view →
COAD	Female	All	−0.601	<.001	8	view →
KICH	Female	All	−0.967	<.001	7	view →
BLCA	Male	All	−0.544	.001	7	view →
LIHC	All	II,III,IV	+0.534	<.001	7	view →
LUAD	Female	II,III,IV	−0.677	<.001	6	view →
BRCA	Female	All	−0.324	<.001	6	view →
CHOL	Male	All	+1.726	<.001	5	view →
LUSC	All	All	−0.286	<.001	4	view →
READ	Female	All	−0.969	<.001	3	view →
UCEC	All	All	−0.862	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PAFAH1B1–HNSC

Open the HNSC breakdown →