PADI4

Across TCGA patient cohorts, PADI4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,738 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PADI4-associated genes across cancer lineages are ADGRE3, FCGR3B, and S100A12. Each is linked with PADI4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PADI4-to-partner and partner-to-PADI4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PADI4 versus ADGRE3 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI4→partner) and Y-score (partner→PADI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE3 →	+0.866	+1.286	<.001	<.001	3	10
LSCC	FCGR3B →	+1.817	+1.292	<.001	<.001	3	10
GBM	S100A12 →	+1.420	+1.288	<.001	<.001	3	10
GBM	CXCL8 →	+2.478	+1.317	<.001	<.001	3	10
GBM	AQP9 →	+1.440	+1.329	<.001	<.001	3	9
COAD	G0S2 →	+1.559	+0.959	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,738 associations by consensus.

PADI4 vs ADGRE3 — LSCC

Explore this scatter interactively →