PADI4

Across TCGA patient cohorts, PADI4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PADI4-associated genes across cancer lineages are Rab25, XRCC1, and eIF4E. Each is linked with PADI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI4-to-partner and partner-to-PADI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by PADI4-low versus PADI4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI4→partner) and Y-score (partner→PADI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Rab25 →	-0.307	-2.991	.024	.036	3	2
COAD	XRCC1 →	+0.204	+2.820	.001	.035	3	2
UCEC	eIF4E →	+0.197	+2.938	.007	<.001	3	2
UCEC	JNK2 →	+0.255	+2.070	<.001	.001	3	2
UCEC	MEK1 →	+0.483	+3.906	<.001	<.001	3	2
UCEC	Notch1 →	+0.166	+2.070	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Rab25 by PADI4 expression — COAD

Explore this box plot interactively →