PADI4

Across TCGA cell cohorts, PADI4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,236 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PADI4-associated GO terms across cancer lineages are Neutrophil extracellular trap formation, Positive regulation of protein localization to lysosome, and Bone resorption. Each is linked with PADI4 in more than 6 cancer types. Because this analysis shows association rather than direction, both PADI4-to-partner and partner-to-PADI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil extracellular trap formation grouped by PADI4-low versus PADI4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI4→partner) and Y-score (partner→PADI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil extracellular trap formation →	+0.809	+1.711	<.001	<.001	3	7
OESOPHAGUS	Positive regulation of protein localization to lysosome →	+0.118	+0.576	<.001	.008	3	4
BLOOD_Leukemia	Bone resorption →	+0.085	+1.327	<.001	<.001	3	4
BLOOD_Leukemia	Complement-mediated synapse pruning →	+0.673	+1.329	<.001	<.001	3	4
BLOOD_Leukemia	Vertebrate eye-specific patterning →	+0.702	+1.358	<.001	<.001	3	4
STOMACH	Response to topologically incorrect protein →	+0.072	+0.203	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,236 associations by consensus.

Neutrophil extracellular trap formation by PADI4 expression — BLOOD_Leukemia

Explore this box plot interactively →