PADI2

Across TCGA patient cohorts, PADI2 mutation is significantly associated with the RNA expression of many other genes, with 2,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PADI2-associated genes across cancer lineages are CENPU, CTLA4, and MAPRE3. Each is linked with PADI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PADI2-to-partner and partner-to-PADI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by PADI2-low versus PADI2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI2→partner) and Y-score (partner→PADI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CENPU →	+0.675	+3.738	.005	<.001	3	3
UCEC	CTLA4 →	+0.647	+2.818	<.001	.001	3	3
UCEC	MAPRE3 →	-0.774	-2.392	<.001	<.001	3	3
UCEC	CKS2 →	+0.692	+2.432	<.001	<.001	3	3
STAD	SNORD82 →	+0.704	+3.158	<.001	.002	3	2
STAD	RNU6-1081P →	+0.360	+2.710	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,073 associations by consensus.

CENPU by PADI2 expression — SKCM

Explore this box plot interactively →