PACSIN1

Across TCGA patient cohorts, PACSIN1 mutation is significantly associated with the RNA expression of many other genes, with 1,879 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACSIN1-associated genes across cancer lineages are MIR551A, DHRS11, and CENPU. Each is linked with PACSIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PACSIN1-to-partner and partner-to-PACSIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR551A grouped by PACSIN1-low versus PACSIN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN1→partner) and Y-score (partner→PACSIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR551A →	+0.375	+6.162	<.001	.002	3	3
UCEC	DHRS11 →	+0.472	+2.732	.002	.003	3	2
UCEC	CENPU →	+0.764	+3.850	<.001	<.001	3	2
UCEC	DPEP1 →	-1.166	-3.392	.002	<.001	3	2
UCEC	BUB3 →	+0.451	+3.775	.001	<.001	3	2
UCEC	SLBP →	+0.607	+3.732	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,879 associations by consensus.

MIR551A by PACSIN1 expression — BRCA

Explore this box plot interactively →