PACSIN1

Across TCGA pan-cancer cohorts, PACSIN1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PACSIN1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PACSIN1 RNA is repressed in tumor relative to normal tissue. In most cancer types PACSIN1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and UCEC are the cancer types where PACSIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PACSIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.567	<.001	10	view →
LUAD	Female	All	+0.948	<.001	9	view →
UCEC	All	III,IV	+2.825	<.001	6	view →
BRCA	All	III,IV	+1.411	<.001	6	view →
LUSC	All	All	+0.712	<.001	5	view →
THCA	All	III,IV	+0.688	<.001	5	view →
CHOL	All	All	+0.535	.002	5	view →
LIHC	All	All	+0.501	<.001	5	view →
KICH	All	II,III,IV	−0.481	.006	3	view →
KIRC	All	II,III,IV	+0.272	.028	3	view →
BLCA	All	All	+0.618	.047	2	view →
KIRP	All	All	+0.407	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PACSIN1–COAD

Open the COAD breakdown →